Delays in diagnosis and treatment of ATTR cardiac amyloidosis: A real-world data analysis.

ABSTRACT:

Aims and background

Cardiac amyloidosis leads to functional cardiac impairment and heart failure. Transthyretin amyloid cardiomyopathy (ATTR-CM) is the most common form. After initial suspicion, diagnosis involves imaging techniques, biopsy and genetic tests, prompting transthyretin stabilizer therapy to slow disease progression. The study aims to assess delays in diagnosis in ATTR-CM patients.

Methods

Patients with ATTR-CM receiving transthyretin stabilizer therapy at the West German Amyloidosis Center (01/2018-12/2023) were included. Clinical, laboratory, and imaging data were analysed. Diagnostic timelines were compared across two periods (2018-2020 and 2021-2023).

Results

After screening 254 patients, 154 were included in the analysis. ATTRwt was the most common f

SUBMITTER: Vogel J 

PROVIDER: S-EPMC12287846 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature