The Prevalence, Distribution, and Clinicopathological Features of Seven Lung Cancer Actionable Driver Mutations in Taiwan.

ABSTRACT:

Background

Efficient and affordable diagnosis, coupled with a clear understanding of driver gene prevalence, distribution, and clinicopathological features of driver genes, is crucial for lung cancer treatment and prevention. This study developed a cost-effective targeted sequencing assay for actionable driver mutation and investigated EGFR, KRAS, NRAS, BRAF, PIK3CA, MET, and HER2 in a southern Taiwanese lung cancer population.

Materials and methods

Two hundred and twenty-three lung cancer specimens from Chang Gung Memorial Hospital, Chiayi (2009-2020), were retrospectively analyzed.

Results

Among the 223 patients, the mutation frequencies detected by the optimized targeted sequencing assay were: EGFR 48.88%, KRAS 6.28%, PIK3CA 5.83%, NRAS and BRAF both 1.79%, MET 0.9

SUBMITTER: Lin YC 

PROVIDER: S-EPMC12287865 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature