Atrial fibrillation development in the heart failure population from nationwide British linked electronic health records.

ABSTRACT:

Aims

Atrial fibrillation (AF) is a frequent comorbidity in heart failure (HF). We analysed factors associated with new-onset atrial fibrillation in patients with heart failure using linked real-world UK data from primary and secondary care, along with findings from genome-wide association studies.

Methods and results

Among 163 174 participants with a diagnosis of HF (January 1998 to May 2016) from Clinical Practice Research Datalink (CPRD) and Hospital Episodes Statistics (HES), 111 595 participants had no previous history of AF (mean age 76.3 ± 12.6; 50.3% women; 95.8% white ethnicity). Multivariate weighted Cox regression was used to identify predictors for new-onset AF. Linkage disequilibrium score regression was performed to assess the strength of the genetic correlation

SUBMITTER: Yoshimura H 

PROVIDER: S-EPMC12287870 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature