Exploring the roles of snoRNA-induced ribosome heterogeneity in equine osteoarthritis.

ABSTRACT:

Introduction

Osteoarthritis (OA) is a degenerative joint disease that greatly contributes to equine morbidity and poor welfare. Changes in cellular protein expression programs fuel the development and progression of OA. Small nucleolar RNAs (snoRNAs) are emerging as important regulators of OA (patho)biology. SnoRNAs are short non-coding RNAs that guide post-transcriptional modifications (PTMs) of ribosomal RNA (rRNA) nucleotides, which impact ribosome function and thus cellular protein expression programs. There is only very limited data on snoRNAs in equine OA.

Methods

In this study, we induced OA in horses (n = 9) using a well-established equine carpal osteochondral fragment model of OA. We collected synovial fluid (SF) before (Day 0) and after OA-inducing surgery (

SUBMITTER: Chabronova A 

PROVIDER: S-EPMC12288042 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature