An Observational Analysis of a Large Cohort of <i>Pneumocystis jirovecii</i> Pneumonia.

ABSTRACT:

Background

Pneumocystis jirovecii pneumonia (PCP) is increasingly seen in patients who are non-HIV immunocompromised hosts, yet modern risk factors and outcomes are poorly recognized and defined.

Methods

A retrospective review was conducted of adult patients who met criteria for proven or probable PCP from 2017 to 2024 across a large academic multicenter health system. The primary outcome was mortality among cohorts, defined by etiology of immunosuppression through univariate and age-adjusted logistic regression. Secondary analyses included trends in annual diagnoses and testing patterns.

Results

A total of 701 patients met criteria for inclusion, representing one of the largest clinically characterized cohorts of PCP to date. The median age was 65 years (IQR,

SUBMITTER: Pulsipher AM 

PROVIDER: S-EPMC12288125 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature