Causal relationship between gastroesophageal reflux disease and IgA nephropathy: a Mendelian randomization analysis.

ABSTRACT:

Background

IgA nephropathy (IgAN) incidence is higher in gastroesophageal reflux disease (GERD) patients than those without. However, the causal link between them is unclear. This study aims to elucidate the causal relationship between GERD and IgAN through bidirectional Mendelian randomization (MR) analysis.

Methods

The chi-square test was employed to assess whether the incidence of IgAN was associated with GERD. Multivariate logistic regression was used to assess whether GERD is an independent risk factor for IgAN. Univariable and multivariable MR analyses were conducted to estimate the associations between GERD and IgAN. The MR analysis included inverse-variance weighted, MR-Egger, weighted median, simple mode, and weighted mode methods. Additionally, pleiotropy, heteroge

SUBMITTER: Han Q 

PROVIDER: S-EPMC12288176 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature