Multi-omics study of mitochondrial dysfunction in the pathogenesis of hyperuricemia.

ABSTRACT:

Background

Mitochondrial dysfunction is linked to hyperuricemia (HUA), but its genetic pathophysiology is not yet fully understood. We employed Mendelian randomization (MR) to integrate multi-omics data and explore the associations between mitochondrial-related genes and HUA.

Methods

We conducted a summary data-based MR analysis to investigate potential targets associated with HUA by integrating mitochondrial-related DNA methylation, gene expression, and protein quantitative trait loci. Additionally, to further explore the potential associations between DNA methylation, gene expression, and protein abundance, we performed MR and co-localization analyses to examine causal relationships between candidate gene methylation and expression, as well as between gene expression and p

SUBMITTER: Hong Y 

PROVIDER: S-EPMC12288190 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature