Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.

ABSTRACT:

Aims

The etiology of osteoarthritis (OA) remains unclear, involving a complex interaction of environmental and genetic factors. Observational studies have contributed substantially to identify modifiable risk factors that were associated with OA risk, but conclusions about the causality are hard to draw as these observed associations are susceptible to be interfered with reverse causality and residual confounding.

Methods

Mendelian randomization (MR) is a valid approach to provide evidence on causal associations, by using genetic variants as 'proxies' for modifiable exposures to examine the effect of genetic susceptibility to the exposures on the outcomes. Such a method provides an opportunity to elucidate OA pathogenesis and therefore to provide evidence for novel intervent

SUBMITTER: Liu H 

PROVIDER: S-EPMC12288192 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature