Optimizing antibiotic duration and percutaneous nephrostomy timing in urosepsis complicated by upper ureteral stones: a retrospective study.

ABSTRACT:

Background

Urosepsis is a potentially life-threatening condition caused by urinary tract infections and is usually associated with urolithiasis-induced obstruction. No established guidelines exist regarding the optimal timing of antibiotic administration, appropriate duration of urinary drainage, or scheduling of definitive ureteroscopic lithotripsy (URSL) in patients with urolithiasis-induced obstructive acute pyelonephritis (APN). Therefore, this study aimed to investigate the key factors influencing the management of urosepsis secondary to upper ureteral stones, specifically focusing on the optimal duration of antibiotic therapy, risk factors for post-URSL fever, and timing of percutaneous nephrostomy (PCN) drainage to improve clinical outcomes.

Methods

This retrospective

SUBMITTER: Hsu JT 

PROVIDER: S-EPMC12288258 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature