Predictors of lipoprotein(a) variability in clinical practice and their impact on cardiovascular risk.

ABSTRACT:

Background

Lipoprotein(a) (Lp[a]) is an established cardiovascular risk marker; however, its intraindividual variability and implications for risk stratification remain poorly understood. This study investigated the clinical and biochemical predictors of high Lp(a) levels and evaluated their potential roles in cardiovascular risk assessment to inform evidence-based public health strategies for cardiovascular disease prevention.

Methods

This retrospective multicenter observational study was conducted using data from three tertiary university hospitals in Korea. Patients with at least two Lp(a) measurements taken ≥ 90 days apart were included (n = 5,305). High Lp(a)-level variability was defined as an absolute change of > 10 mg/dL and a relative change of > 25%. Predictors of

SUBMITTER: Joo HJ 

PROVIDER: S-EPMC12288285 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature