Genotype-specific retinal and choroidal perfusion patterns in inherited retinal diseases: an SS-OCTA analysis.

ABSTRACT:

Background

Retinitis pigmentosa (RP), an inherited retinal disease, is characterized by progressive vision loss driven by the gradual degeneration of retinal photoreceptors. This process manifests as impaired dark adaptation, night blindness, constriction of the visual field, and the deterioration of central vision. Although the progression can be monitored by electroretinography (ERG), visual field (VF) tests and optical coherence tomography (OCT) to some extent, it's hard to achieve high repeatability. Considering the correlation between patients' retinal blood volume and their visual function, OCT angiography (OCTA) can be a good choice for monitoring RP progression by objectively quantifying vascular changes.

Methods

This study included 62 patients and 21 matched control

SUBMITTER: Rong Y 

PROVIDER: S-EPMC12288356 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature