Black Tea Aqueous Extract Extends Yeast Longevity via Antioxidant Gene Activation: Transcriptomic Analysis of Anti-Aging Mechanisms.

ABSTRACT: Although tea polyphenols have antiaging potential, the molecular interplay between black tea components and cellular longevity remains unclear. This study has pioneered a dual approach combining Saccharomyces cerevisiae lifespan assays with comprehensive transcriptomics to dissect how black tea aqueous extract (BTAE) extends the chronological lifespan (CLS). Remarkably, BTAE induced a dose-dependent lifespan extension (34.6% maximum at 40 μg/mL), coupled with a 62% reduction in reactive oxygen species (ROS) accumulation and enhanced superoxide dismutase/catalase/ascorbate peroxidase (SOD/CAT/APX) enzyme activities-hallmarks of antioxidant system activation. Transcriptomic profiling revealed the action mechanism of BTAE: (1) upregulation of oxidative defense arsenals (SOD1/

SUBMITTER: Li J 

PROVIDER: S-EPMC12288370 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature