The cell wall hydrolase MltG is essential to maintain cell wall homeostasis of <i>Enterococcus faecalis</i>.

ABSTRACT: Infections caused by enterococci are increasingly prevalent and difficult to treat due to multidrug resistance. Enterococcus faecalis exhibits intrinsic resistance toward cephalosporins, which inhibit the final step of peptidoglycan (PG) synthesis. Intrinsic resistance requires multiple factors in the PG synthesis pathway and at least two cell-wall-stress signal transduction systems; however, the complete molecular mechanism of enterococcal cephalosporin resistance remains to be elucidated. MltG, a predicted PG hydrolase, is thought to process nascent strands of PG, suggesting that MltG might play an important role in enterococcal cell wall homeostasis and potentially cephalosporin resistance. Here, we demonstrate that enterococcal MltG cleaves nascent PG. An E. faecalis muta

SUBMITTER: Knotek AAU 

PROVIDER: S-EPMC12288455 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature