EzrA promotes Z-ring formation through interaction of its QNR motif with FtsA.

ABSTRACT: Bacterial cell division requires precise placement and formation of the division machinery to ensure the accurate generation of identical daughter cells. This process is canonically initiated by the highly conserved FtsZ but also needs the involvement of a variety of FtsZ-binding proteins to orchestrate the spatial and temporal positioning and assembly of the Z-ring. However, the underlying molecular mechanisms remain poorly understood. In this study, we characterized the roles of an important FtsZ binding protein EzrA in the cell division of Streptococcus suis, an emerging zoonotic bacterial pathogen. Our results revealed that EzrA shares high subcellular dynamics with FtsZ during the entire cell division cycle and functions primarily as a positive regulator for Z-ring formation. C

SUBMITTER: Li T 

PROVIDER: S-EPMC12288466 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature