<i>Apteranthes tuberculata</i>'s Antidiabetic Potential: Exploring Phytochemicals, Screening Antioxidant Activity, and Validating DPP-4 Inhibition Using In Vitro and In Silico Approaches.

ABSTRACT: Diabetes is a chronic metabolic disorder that affects an increasing number of people worldwide, frequently managed with synthetic drugs that have side effects and can be costly. Apteranthes tuberculata (N.E.Br.) Meve & Liede, a plant with traditional medicinal use in Pakistan to treat diabetes, but its antidiabetic potential has not been scientifically validated. This research assessed the phytochemicals, antioxidant properties, and dipeptidyl peptidase-4 (DPP-4) inhibitory activity of A. tuberculata's methanolic extract. The extract was assessed through in vitro antioxidant assays, DPP-4 inhibition test, and metabolomic analysis via Fourier-transform infrared (FTIR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). The study used computational tools to visual

SUBMITTER: Khan I 

PROVIDER: S-EPMC12288619 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature