White matter microstructural associations with pain experiences in a large community sample of youth.

ABSTRACT:

Abstract

Pain experiences in adolescence are increasing and represent a major public health concern. However, little is known about the neurobiological phenotype of pain experiences in adolescents, particularly outside of a clinical setting. A better neurobiological understanding of pain experiences in community youth may shed light on potential vulnerabilities present before clinical diagnoses of chronic pain. This study utilized an exploratory region-of-interest approach, in a large community sample (n = 7332) of youth (ages 11-12), to examine the association between white matter microstructure, fractional anisotropy (FA) and mean diffusivity (MD), and pain experiences. Bayesian multilevel modeling was used to explore group differences (between those reporting past-month pain and

SUBMITTER: Jones SA 

PROVIDER: S-EPMC12288759 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature