Molecular mechanisms of Eda-mediated adaptation to freshwater in threespine stickleback.

ABSTRACT: A main goal of evolutionary biology is to understand the genetic basis of adaptive evolution. Although the genes that underlie some adaptive phenotypes are now known, the molecular pathways and regulatory mechanisms mediating the phenotypic effects of those genes often remain a black box. Unveiling this black box is necessary to fully understand the genetic basis of adaptive phenotypes, and to understand why particular genes might be used during phenotypic evolution. Here, we investigated which genes and regulatory mechanisms are mediating the phenotypic effects of the Eda haplotype, a locus responsible for the loss of lateral plates and changes in the sensory lateral line of freshwater threespine stickleback (Gasterosteus aculeatus) populations. Using a combination of RNAseq and a cross d

SUBMITTER: Rodriguez-Ramirez CE 

PROVIDER: S-EPMC12288785 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature