Gene Expression at the Tripartite Synapse: Bridging the Gap Between Neurons and Astrocytes.

ABSTRACT: Astrocytes, a major class of glial cells, are an important element at the synapse where they engage in bidirectional crosstalk with neurons to regulate numerous aspects of neurotransmission, circuit function, and behavior. Mutations in synapse-related genes expressed in both neurons and astrocytes are central factors in a vast number of neurological disorders, making the proteins that they encode prominent targets for therapeutic intervention. Yet, while the roles of many of these synaptic proteins in neurons are well established, the functions of the same proteins in astrocytes are largely unknown. This gap in knowledge must be addressed to refine therapeutic approaches. In this chapter, we integrate multiomic meta-analysis and a comprehensive overview of current literature to show that a

SUBMITTER: Imrie G 

PROVIDER: S-EPMC12289143 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature