Identifying genetic variations in <i>emm</i>89 <i>Streptococcus pyogenes</i> associated with severe invasive infections.

ABSTRACT: Streptococcus pyogenes causes mild human infections as well as life-threatening invasive diseases. Since the mutations known to enhance virulence to date account for only half of the severe invasive infections, additional mechanisms/mutations need to be identified. Here, we conducted a genome-wide association study of emm89 S. pyogenes strains to comprehensively identify pathology-related bacterial genetic factors (single-nucleotide polymorphisms [SNPs], indels, genes, or k-mers). Japanese (n = 311) and global (n = 666) cohort studies of strains isolated from invasive or non-invasive infections revealed 17 and 1075 SNPs/indels and 2 and 169 genes, respectively, that displayed associations with invasiveness. We validated one of them, a non-invasiveness-rel

SUBMITTER: Ono M 

PROVIDER: S-EPMC12289306 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature