Coordinated <i>Tbx3/Tbx5</i> transcriptional control of the adult ventricular conduction system.

ABSTRACT: The cardiac conduction system (CCS) orchestrates the electrical impulses that enable coordinated contraction of the cardiac chambers. The T-box transcription factors TBX3 and TBX5 are required for CCS development and associated with overlapping and distinct human CCS diseases. We evaluated the coordinated role of Tbx3 and Tbx5 in the murine ventricular conduction system (VCS). We engineered a compound Tbx3:Tbx5 conditional knockout allele for both genes located in cis on mouse chromosome 5. Conditional deletion of both T-box transcriptional factors in the VCS, using the VCS-specific MinK^CreERT2, caused loss of VCS function and molecular identity. Combined Tbx3 and Tbx5 deficiency in the adult VCS led to conduction defects,

SUBMITTER: Burnicka-Turek O 

PROVIDER: S-EPMC12289313 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature