Patient characteristics associated with conventional schedule vs. dose dense chemotherapy in women with stage I-IIIA breast cancer.

ABSTRACT:

Introduction

Compared to conventional chemotherapy schedules, use of dose-dense chemotherapy, which refers to administration of chemotherapy at standard doses with reduced cycle lengths, is known to improve survival, although may confer greater toxicity risk. We evaluated the patient factors associated with use of conventional vs. dose-dense chemotherapy administration schedules.

Methods

Analyses include 4685 women treated with adjuvant chemotherapy between 2005 and 2019 for Stage I-IIIA breast cancer at Kaiser Permanente Northern California and Kaiser Permanente Washington. Among women treated with drug combinations for which dose-dense administration schedules were observed, we used generalized linear models of the Poisson family with a log-link function to calculate preva

SUBMITTER: Bhimani J 

PROVIDER: S-EPMC12289320 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature