Blood Pressure Targets for Adults with Vasodilatory Shock - An Individual Patient Data Meta-Analysis.

ABSTRACT:

Background

We sought to estimate whether a lower mean arterial blood pressure target, compared with a higher mean arterial blood pressure target, reduced 90-day all-cause mortality among critically ill adult patients with vasodilatory shock.

Methods

We conducted an individual patient data meta-analysis of randomized controlled trials that evaluated the effect of distinct thresholds of mean arterial blood pressure to guide vasopressor support among critically ill adults identified in a systematic literature search. The main exposure was a lower mean arterial pressure target compared with a higher mean arterial pressure target (including usual care). The primary outcome was 90-day all-cause mortality. We used a Bayesian random effects log-binomial model to estimate risk ratios

SUBMITTER: Angriman F 

PROVIDER: S-EPMC12289332 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature