Kynurenic Acid Is a Predictive Prognostic Metabolic Marker in ST-Elevation Myocardial Infarction.

ABSTRACT: Background: The tryptophan/kynurenic acid (KYNA) pathway plays a crucial role by modulating inflammation, oxidative stress, and immune activation. The clinical value of tryptophan metabolites in the KYNA pathway for the early diagnosis and prognosis of STEMI patients, as well as the underlying functional mechanisms, remains to be elucidated. Objectives: This study evaluated the prognostic value of KYNA, a metabolite of the tryptophan pathway, in STEMI patients. Methods: Untargeted metabolomics by ¹H-nuclear magnetic resonance (NMR) analysis was used to examine metabolite changes between 50 control subjects and 50 STEMI patients with an onset time of < 3 h. Furthermore, targeted metabolomic analysis was employed to investigate the association between KYNA and

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12289359 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature