ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas.

ABSTRACT:

Background

Gliomas are the most prevalent and aggressive primary brain tumors. Aging significantly influences glioma incidence and progression, yet the molecular mechanisms linking aging-related pathways to tumor aggressiveness remain poorly understood. Here, we aimed to decipher aging-related molecular mechanisms regulating tumor aggressiveness in gliomas.

Methods

We performed comprehensive aging-targeted transcriptomic analyses using TCGA-glioma patient dataset. Differential gene and protein expression, functional annotation and pathway enrichment, gene set enrichment, network construction, CRSISPR-based functional dependency, transcription factor prediction, correlation, clinical association and survival analyses were conducted to identify, develop and validate endoplasmi

SUBMITTER: Shao X 

PROVIDER: S-EPMC12289514 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature