<i>Lactobacillus rhamnosus</i> Glory LG12 preventives loperamide-induced constipation in mice by modulating intestinal flora and metabolic pathways.

ABSTRACT:

Introduction

Constipation is a common gastrointestinal disease, the incidence of which has been increasing year by year in recent years, and prolonged constipation seriously affects the physical and mental health of patients. Constipation often leads to dysbiosis of the intestinal flora, which in turn exacerbates intestinal dysfunction, and this may be an important mechanism for the development of constipation. Studies have shown that probiotics may be effective in relieving constipation by regulating intestinal flora. Among them, Lacticaseibacillus rhamnosus Glory LG12 (L. rhamnosus Glory LG12), as a potential probiotic strain, has attracted much attention in regulating intestinal flora and improving intestinal function. Although it has shown potential in the treatme

SUBMITTER: Ma W 

PROVIDER: S-EPMC12289570 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature