Exploratory analysis of potential association between oral Haemophilus and sleep disturbances in major depressive disorder patients.

ABSTRACT:

Background

The current study aimed to explore the specific oral microbiota profiles in major depressive disorder (MDD) patients with sleep disturbances, and to evaluate the potential mechanisms by which oral microbiota may be implicated in MDD.

Method

Thirty-eight MDD patients experiencing sleep disturbances and thirty healthy controls (HCs) were included. All MDD patients underwent a 14-day antidepressive treatment regimen. Neuropsychological assessments were conducted, and 16S rRNA sequencing was used to determine the abundance of oral bacteria.

Results

Oral genera Solobacterium, Granulicatella, Campylobacter, and Haemophilus showed significant changes in their relative abundances between the MDD and HC groups. Significant correlations we

SUBMITTER: Shi Y 

PROVIDER: S-EPMC12289620 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature