Identifying clinically relevant subgroups of patients with knee pain flares for ibuprofen treatment: a secondary analysis.

ABSTRACT:

Objective

We aimed to evaluate whether subgroups with more severe inflammatory symptoms during a knee pain flare benefited more from a high dose ibuprofen treatment than subgroups with less severe inflammatory symptoms.

Methods

This secondary analysis included adults with ≥ 1 flares of knee pain in the last year, who experienced a new episode within 24 h and randomized into two treatment groups of daily ibuprofen 1200 mg or 2400 mg for 5 days. A multilevel regression analysis was used to assess interaction effects between intervention groups and pre-defined subgroups, based on osteoarthritis related symptoms (severity of morning stiffness, swelling, and pain). The primary outcome was the difference in treatment effect between subgroups on pain severity (0-10 on the numeric r

SUBMITTER: Sharma RU 

PROVIDER: S-EPMC12289777 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature