High mobility group protein 2 (HMGA2) is highly expressed in a broad range of benign and malignant tumors.

ABSTRACT: High mobility group protein 2 (HMGA2) is an essential component of the enhanceosome that regulates gene transcription during organ development, and its re-expression in adult tissues is often linked to tumor formation and progression. To investigate HMGA2's role in cancer, a tissue microarray of 18,582 samples from 154 tumor types and 608 samples from 76 normal tissues was analyzed. HMGA2 expression was generally higher in cancer than in normal tissues. Of the 15,915 tumor samples, 37.5% showed HMGA2 positivity: 12% weak, 11.5% moderate, and 13.9% strong. HMGA2 was detected in at least one case in 118 of 144 tumor categories, with strong staining in 92 categories. The frequency of HMGA2 positivity was highest in cancers of the ovary and the endometrium (52.6-92.6%), thyroidal neoplasms (53

SUBMITTER: Chirico V 

PROVIDER: S-EPMC12289817 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature