Microstructural abnormalities in multiple system atrophy as revealed by conventional and rotating frame relaxation MRI parameters.

ABSTRACT: Rotating frame relaxation (RFR) techniques provide robust and sensitive quantitative MRI (qMRI) metrics able to detect subtle alterations of brain tissue integrity in multiple neurological disorders. We performed a cross-sectional qMRI study in 16 patients with Multiple System Atrophy (MSA) and 14 age- and sex-matched healthy controls. The MRI protocol included the acquisition of RFR metrics, namely adiabatic T1ρ and T2ρ relaxation time constants, along with the acquisition of conventional relaxation metrics, namely R1 and R2*, and a semi-quantitative metric describing magnetization transfer (MT). Between-group comparisons of voxel-based and region-based outcomes were obtained both with and without accounting for the effect of atrophy. Significant brain atrophy was observed in the MSA pati

SUBMITTER: Canna A 

PROVIDER: S-EPMC12289937 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature