Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data.

ABSTRACT: Early prediction of disability progression in multiple sclerosis (MS) remains challenging despite its critical importance for therapeutic decision-making. We present the first systematic evaluation of personalized federated learning (PFL) for 2-year MS disability progression prediction, leveraging multi-center real-world data from over 26,000 patients. While conventional federated learning (FL) enables privacy-aware collaborative modeling, it remains vulnerable to institutional data heterogeneity. PFL overcomes this challenge by adapting shared models to local data distributions without compromising privacy. We evaluated two personalization strategies: a novel AdaptiveDualBranchNet architecture with selective parameter sharing, and personalized fine-tuning of global models, benchmarked aga

SUBMITTER: Pirmani A 

PROVIDER: S-EPMC12289948 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature