Pharmacovigilance of drug-induced cataract using the FDA Adverse Event Reporting System.

ABSTRACT: Cataract is a leading cause of irreversible vision loss, particularly among the elderly, with drug-induced cataract being an underrecognized yet significant contributor to visual impairment. This study investigates the associations between medications and cataract development using real-world data from the FDA Adverse Event Reporting System (FAERS) from Q1 2004 to Q3 2024. A total of 54,800 reports were analyzed, including 2,336 cases involving 691 drugs in individuals aged 0-45 years. Disproportionality analysis identified 24 drugs significantly associated with cataract risk, with the highest risks linked to glucocorticoids (e.g., fluticasone furoate, triamcinolone), insulin analogs (e.g., insulin glargine, insulin human), and other agents like nitisinone and ranibizumab. Difluprednate sh

SUBMITTER: Hong SY 

PROVIDER: S-EPMC12289960 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature