Independent and medication related effects of bipolar disorder on thyroid and reproductive hormones in women.

ABSTRACT: This study aimed to explore the relationship between Bipolar Disorder (BD) and endocrine hormones, as well as the relationship between psychotropics and endocrine hormones. We recruited 55 drug-naïve women patients with BD, 66 long-term medicated women patients with BD, and 53 healthy controls. Serum levels of thyroid hormones, reproductive hormones, and insulin were measured in all participants. Clinical symptoms of depression and mania were measured in all patients with BD. After controlling for confounding factors, drug-naïve patients showed higher levels of free triiodothyronine (FT3), FT3/free thyroxine (FT4), and luteinizing hormone (LH) than controls, and medicated patients showed higher levels of FT3/FT4, thyroid stimulating hormone (TSH), anti-müllerian hormone (AMH), and insulin

SUBMITTER: Yang M 

PROVIDER: S-EPMC12289967 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature