Nanowhisker glues for fatigue-resistant bioadhesion and interfacial functionalization.

ABSTRACT: Fatigue-resistant functional bioadhesion is desired in diverse applications ranging from wound management to wearable devices. Nanoparticle-based bioadhesives offer versatile functionality but suffer from weak adhesion and fatigue vulnerability due to tissue barriers and poor tissue interactions. Polymer chain-based bioadhesives can form tough bioadhesion but remain vulnerable to fatigue fracture. Here we demonstrate that rationally designed chitosan nanowhiskers glues achieve fatigue-resistant bioadhesion and interfacial functionalization via the combined high aspect ratio, rigidity, polymer-binding and network-forming properties. We deploy these glues using chemical enhancers, microneedle rollers, and ultrasound, enabling strong tissue anchorage despite tissue barriers. At low concentrat

SUBMITTER: Jiang S 

PROVIDER: S-EPMC12290001 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature