A single-cell V(D)J sequencing dataset of peripheral blood cells in  multibacillary leprosy.

ABSTRACT: Leprosy is a chronic infectious disease caused by Mycobacterium leprae (Mlep), and is classified as a tropical disease by the WHO. While prior research has documented the various phenotypes and functions of T cells and B cells in Mlep infection, the specific clonotypes of T cells and B cells that are essential for understanding the progression of multibacillary leprosy have not been reported. Here, we established a single-cell V(D)J sequencing dataset including 5 multibacillary leprosy patients (MBs) and 5 healthy individuals (HCs), aiming to generate comprehensive profiles of T-cell receptors and B-cell receptors present in the peripheral blood. This study suggested that Mlep infection has distinct selective effects on peripheral immune repertoires and that these biased immune repertoires

SUBMITTER: Li Z 

PROVIDER: S-EPMC12290026 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature