DNMT1-mediated regulation of somatostatin-positive interneuron migration impacts cortical architecture and function.

ABSTRACT: The coordinated development of cortical circuits composed of excitatory and inhibitory neurons is critical for proper brain function, and disruptions are linked to a spectrum of neuropsychiatric disorders. While excitatory neurons are generated locally in the cortical proliferative zones, inhibitory cortical interneurons (cINs) originate in the basal telencephalon and migrate tangentially into the cortex. Here, we show that DNA methyltransferase 1 (DNMT1) is essential for the migration and integration of somatostatin (SST)-expressing interneurons in mice. Dnmt1 deletion causes premature exit of SST⁺ cINs from the superficial migratory stream and alters the expression of key developmental genes. Unexpectedly, Dnmt1-deficient SST⁺ interneurons also exert non-cell-autono

SUBMITTER: Reichard J 

PROVIDER: S-EPMC12290092 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature