Shared blood gene signature in lung adenocarcinoma and microbial lung infections: a bioinformatic analysis and in silico validation.

ABSTRACT:

Background

Microbial lung infections may promote development of lung cancer through overlapping molecular mechanisms. This analysis aimed to identify a co-regulated peripheral blood gene signature in lung adenocarcinoma (LUAD) and microbial lung infections.

Methods

A total of 403 peripheral blood transcriptomic profiles from five GEO test datasets-two LUAD (GSE39345, GSE103527) and three infection-related (GSE40012, GSE65682, GSE103119)-were analyzed using the limma package. Differentially expressed genes (DEGs) were defined by|log₂FC| >1 and p < 0.05. Two additional GEO datasets (GSE42826 and GSE42830), comprising 30 blood samples (16 LUAD, 14 lung infection), served as validation sets. Shared DEGs were subjected to KEGG and GO enrichment analyses. Protein-protei

SUBMITTER: Sheervalilou M 

PROVIDER: S-EPMC12290164 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature