Survivin (BIRC5) Gene Polymorphism (rs9904341) Is Associated with Cancer Risk: A Meta-Analysis.

ABSTRACT:

Introduction

Survivin (BIRC5) is an anti-apoptosis protein over expressed in most cancers and associated with poor clinical outcomes. We have provided an updated meta-analysis of -31G/C (rs9904341) gene polymorphism which is highly associated with cancer risk.

Methodology

A comprehensive literature search in PubMed and Google Scholar databases was conducted. A total of 10472 cases and 12193 controls from 51 studies were included in this meta-analysis. This study was prospectively registered in PROSPERO, and sensitivity analysis, risk of bias analysis, and statistical analysis were performed. A pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to assess the strength of the association. All analyses were achieved using RevMan 5.4 software and Excel 2013 v

SUBMITTER: Malviya N 

PROVIDER: S-EPMC12290173 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature