In Silico Analysis Revealed a Role for NUSAP1 in Lung Adenocarcinoma through E2F1/hsa-let-7b-5p/lncRNA-TMPO-AS1.

ABSTRACT:

Objectives

Nucleolar and spindle-associated protein 1 (NUSAP1) is crucial for chromosomal segregation and spindle assembly, its expression correlates with high morbidity and mortality rates, necessitating better understanding of prognosis-related networks.

Methods

The study used databases like KM Plotter, TNMplot, UALCAN, OncoMX, GEPIA2, OncoDB, ENCORI, TIMER 2.0, CancerSEA, miRNet, CellTracer, TISIDB, GSCA, and the Enrichr database to analyze NUSAP1 expression in lung cancer tumors and normal tissues.

Results

The NUSAP1 gene is overexpressed in both adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). However, LUAD has a poor prognosis for overall survival (OS) (HR = 1.94), first progression (FP) (HR = 1.96), and post-progression survival (PPS) (HR = 1.48), whil

SUBMITTER: Nirmal S 

PROVIDER: S-EPMC12290181 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature