Association of Insertion/Deletion Polymorphisms of MDM2, MCP-1 and VEGF with Esophageal Cancer Risk in North-West Indians: A Case - Control Study.

ABSTRACT:

Background

The carcinogenesis process in esophageal cancer (EC), a highly heterogeneous and multifaceted disease, is influenced by both tumor angiogenesis and chronic inflammation pathways. Genetic variants in these pathways may affect the progression and development of EC, ultimately contributing to different susceptibilities to cancer among individuals.

Methods

In this study, a total of 536 subjects were recruited, including 260 EC patients and 276 healthy individuals. The DNA was isolated from the blood samples of the participants using the standard phenol-chloroform method. The three insertion/deletion (ins/del) polymorphisms (VEGF-2549 18bp I/D, MDM2 40bp I/D, and MCP-1 14bp I/D) were screened using the Direct-polymerase chain reaction (PCR) genotyping method. The role

SUBMITTER: Mahajan D 

PROVIDER: S-EPMC12290200 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature