Cubebin, a Lignan Isolated from , Exhibits Potent and Selective Antiparasitic Activity against.

ABSTRACT: is a zoonotic parasitic nematode of growing global health concern, largely due to the limited efficacy of current anthelmintics such as albendazole. In this study, cubebina dibenzylbutyrolactole lignanwas isolated for the first time from (Winteraceae), a Chilean endemic plant, and evaluated for its antiparasitic activity. Chromatographic purification of fresh leaves yielded cubebin as a 3:2 epimeric mixture, with its structure confirmed by 500 MHz NMR and single-crystal X-ray diffraction. In vitro assays demonstrated potent anthelmintic activity against both first-stage (L1) and infective third-stage (L3) larvae of , with EC₅₀ values of 4.7 and 15.3 μM, respectively, making it approximately three times more potent than albendazole against L1 and comparably effective aga

SUBMITTER: Teixeira TR 

PROVIDER: S-EPMC12290638 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature