Simplified Loop-Mediated Isothermal Amplification-Based Method for Point-of-Care Detection of in Low-Resource Settings.

ABSTRACT: According to the data from the World Health Organization, acute lower respiratory tract infections, such as pneumonia, are the leading causes of death in low- and middle-income countries, where the burden is highest. Adequate treatment of pneumonia requires accurate diagnosis; however, current diagnostic methods do not allow for rapid differentiation of viral and bacterial cause of pneumonia. Therefore, many patients are empirically treated, which leads to the inappropriate use of antibiotics and the acceleration of the emergence of antimicrobial resistance. We aimed to develop a fast and reliable detection method that is fit for purpose in low-resource settings to identify the most common pathogen causing pneumonia, namely . In this study, we developed, optimized, and validated a loop-med

SUBMITTER: Jerabek P 

PROVIDER: S-EPMC12290675 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature