A Low Protein Binding Electrospun Membrane Filter for Efficient Biological Media Sterilization.

ABSTRACT: This study exploited the water repelling hydrophobic nature of polycaprolactone (PCL) fibers for efficient filtration of water-based fluids toward development of an affordable sterile membrane filter by the process of electrospinning. Electrospun (ES) nanosized fibrous membranes of different thicknesses presented high force at break and minimal elongation supported syringe filtration. The membrane hydrophobicity facilitated easy filtration of small volumes of biological fluids (∼1 mL) without any wetting media loss. Compared to commercial filters, the developed electrospun PCL membrane filter (EPF) device exhibited excellent bacterial filtration without compromising the media quality. Electron microscopy analysis revealed bacterial entrapment onto PCL nanofibers that are in direct contact

SUBMITTER: Azeez A 

PROVIDER: S-EPMC12290698 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature