Defining Lifetime Risk Thresholds for Breast Cancer Surgical Prevention.

ABSTRACT:

Importance

Expanding access to genetic testing and availability of validated breast cancer (BC) risk prediction models are increasingly identifying women at elevated BC risk who do not carry high-penetrance BRCA1/BRCA2/PALB2 pathogenic variants. The precise BC risk threshold for offering risk-reducing mastectomy (RRM) for BC prevention is unknown.

Objective

To define the lifetime BC risk thresholds for RRM to be cost-effective compared with nonsurgical alternatives for BC prevention.

Design, setting, and participants

This economic evaluation used a decision-analytic Markov model to compare the cost-effectiveness of RRM with BC screening and medical prevention in a simulated cohort. Extensive sensitivity analyses were performed. The study setting was from a UK payer pe

SUBMITTER: Wei X 

PROVIDER: S-EPMC12290908 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature