Transcriptome Analysis of Triple-Negative HCC1937 and MDA-MB-231 Breast Cancer Cells Treated with Revealed the Regulation of Migration and Invasion via the Downregulation of the Genes JAK2, ROCK1 and ROCK2.

ABSTRACT: Triple-negative breast cancer (TNBC) is a type of breast cancer with high mortality due to aggressive tumor behavior and limited treatment options. Natural products have been studied for their potential as alternatives to combine with cancer drugs to improve treatment efficacy. Plant phytoconstituents can regulate cellular processes such as proliferation, differentiation, invasion, angiogenesis, and migration. has been used in traditional medicine; it contains flavonoids, phenols, alkaloids, glycosides, bufadienolides, and tannins, among others. In the present investigation, we evaluated the effects of aqueous extract and the underlying molecular mechanisms in two breast cancer cell lines, HCC1937 and MDA-MB-231, with a focus on cellular migration. The cytotoxic activity results revealed t

SUBMITTER: Alvizo-Rodriguez C 

PROVIDER: S-EPMC12290928 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature