Differential Modulation of Copper(II) Interactions with the 18-22 Coordinating Amylin Fragment by the Geometric Isomers of a New Nicotinoyl Hydrazone: A First Study.

ABSTRACT: Type 2 diabetes mellitus is a multifactorial disease associated with insulin resistance and pancreatic β-cell dysfunction. Interestingly, this disease has also been associated with the aggregation of islet amyloid polypeptide (IAPP or amylin). This peptide can bind to physiological metal ions such as copper-(II), which enhances its aggregation and induces oxidative stress. For this reason, the use of moderate chelators constitutes a compelling potential therapeutic strategy. In this work, we synthesized and characterized the geometric isomers of a new compound, 1-methylimidazole-2-carboxaldehyde nicotinoyl hydrazone (X1NIC), aiming to evaluate their differential interactions with copper-(II) and the hIAPP_18-22 peptide fragment. Both compounds demonstrated high aque

SUBMITTER: Carvalho A 

PROVIDER: S-EPMC12290932 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature