Molecular Design of Catechol-Containing Phospholipid Polymers toward Effective Functionalization of Magnetic Nanoparticles for Cancer Hyperthermia.

ABSTRACT: Cancer hyperthermia induced through magnetic nanoparticles that generate heat upon irradiation with an alternating magnetic field (AMF) allows local heating of tumor tissues, leading to cancer cell death. For the clinical application of magnetic nanoparticles, designing an appropriate surface structure is important for maintaining colloidal stability and stealth properties that prevent clearance by the mononuclear phagocyte system. Catechol-containing polymers offer stable modification and functionalization of nanoparticles. However, the effect of their molecular structure on the modification efficiency and function of nanoparticles remains unclear. Herein, magnetite nanoparticles (MNPs) modified with a series of catechol-containing polymers composed of dopamine methacrylamide (DMA) units

SUBMITTER: Kaneko M 

PROVIDER: S-EPMC12290941 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature