Deep brain stimulation of the centromedian nucleus for drug-resistant epilepsy in children: Quality-of-life and functional outcomes from the CHILD-DBS registry.

ABSTRACT:

Objective

Deep brain stimulation of the centromedian nucleus of the thalamus (CM-DBS) is an investigational, off-label treatment for drug-resistant epilepsy (DRE) in children. Although emerging evidence supports its safety and efficacy for select indications, the effect of CM-DBS on quality of life and functional outcomes such as school attendance has not been studied. Here, we analyzed data from the prospective CHILD-DBS (Child & Youth Comprehensive Longitudinal Database for Deep Brain Stimulation) to examine the impact of CM-DBS on patient- and caregiver-reported outcomes.

Methods

Twenty-two children and youth underwent bilateral CM-DBS. Caregiver-child dyads completed surveys related to seizure frequency, seizure severity, quality of life, and school attendance at baselin

SUBMITTER: Mithani K 

PROVIDER: S-EPMC12291001 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature