Performance of cryptogenic new onset refractory status epilepticus score in a Brazilian cohort after testing for antineuronal antibodies with tissue-based and cell-based assays.

ABSTRACT:

Objective

This study was undertaken to describe a case series of Brazilian new onset refractory status epilepticus (NORSE) patients and evaluate the sensitivity and specificity of a clinical score to predict cryptogenic etiology (c-NORSE score) after autoimmune encephalitis (AE) testing.

Methods

Thirty-seven patients with NORSE from the Brazilian Autoimmune Encephalitis Network were investigated with brain magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, and complementary testing with tissue-based assays and cell-based assays for antineuronal and antiglial antibodies (abs) in serum/CSF. Final diagnoses were compiled after chart review. Patients were allocated into two groups according to c-NORSE score: (≥5) high score (HS) or (<5) low score (LS), and cli

SUBMITTER: Ferreira JHF 

PROVIDER: S-EPMC12291003 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature