A Novel Hand-Held Spinning Platform with Centrifugal Microfluidics for Rapid, Cost-Effective Urinary Total Protein Detection at the Point of Care.

ABSTRACT: Urinary total protein (UTP) serves as a critical biomarker for diagnosing and managing various diseases; however, current detection methods often face limitations regarding accessibility, cost, and operational complexity for point-of-care applications. This study presents a novel hand-held spinning platform with centrifugal microfluidics (HSP-C^M), a groundbreaking technology designed for electricity-free, cost-effective UTP detection at a remarkably low cost of approximately 1.4 USD per test. The HSP-C^M integrates a 3D-printed spinning device that ensures uniform reagent distribution and a centrifugal microfluidic biochip capable of providing quantitative UTP analysis in a colorimetric, rapid (∼3 min), and user-friendly format. Notable innovations of the system includ

SUBMITTER: Li W 

PROVIDER: S-EPMC12291037 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature