Toward Bioactive Hydrogels: A Tunable Approach via Nucleic Acid-Collagen Complexation.

ABSTRACT:

Purpose

Nucleic acid-collagen complexes (NACCs) are unique biomaterials formed by binding short, monodisperse single-stranded DNA (ssDNA) with type I collagen. These complexes spontaneously generate microfibers and nanoparticles of varying sizes, offering a versatile platform with potential applications in tissue engineering and regenerative medicine. However, the detailed mechanisms behind the nucleic acid-driven assembly of collagen fibers still need to be established. We aim to understand the relationship between microscopic structure and bulk material properties and demonstrate that NACCs can be engineered as mechanically tunable systems.

Methods

We present a study to test NACCs with varying molar ratios of collagen to random ssDNA oligonucleotides. Our methods encompass

SUBMITTER: Pipis N 

PROVIDER: S-EPMC12291172 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature